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Publications: Publications
headache, migrane, trigeminal, cgrp, glutamate, trigeminovascular, cluster headache, tacs, metabolomics, proteomics, electrophysiology, neuralgia, migrane trust, drug discovery, neuromodulation,
headache, migrane, trigeminal, cgrp, glutamate, trigeminovascular, cluster headache, tacs, metabolomics, proteomics, electrophysiology, neuralgia, migrane trust, drug discovery, neuromodulation,


  • Lambru G., Benemei S., Andreou A.P., Luciani M., Serafini G., Maassen van den Brink A.  Martelletti P.  Position Paper on Post-Traumatic Headache: The Relationship Between Head Trauma, Stress Disorder, and Migraine. Pain Ther . DOI:  10.1007/s40122-020-00220-1

  • Lloyd, J. O., K. I. Chisholm, B. Oehle, M. G. Jones, B. N. Okine, A. Al-Kaisy, G. Lambru, S. B. McMahon and A. P. Andreou. "Cortical Mechanisms of Single-Pulse Transcranial Magnetic Stimulation in Migraine." Neurotherapeutics. DOI: 10.1007/s13311-020-00879-6

  • Summ, O., A. P. Andreou, S. Akerman, P. R. Holland, J. Hoffmann and P. J. Goadsby. "Differential actions of indomethacin: clinical relevance in headache." Pain. DOI: 10.1097/j.pain.0000000000002032

  • Alstadhaug, K. B., H. K. Ofte, K. I. Muller and A. P. Andreou. "Sudden Caffeine Withdrawal Triggers Migraine-A Randomized Controlled Trial." Front Neurol 11: 1002 DOI: 10.3389/fneur.2020.01002

  • Andreou, A. P., C. Leese, R. Greco, C. Demartini, E. Corrie, D. Simsek, A. Zanaboni, K. Koroleva, J. O. Lloyd, G. Lambru, C. Doran, O. Gafurov, E. Seward, R. Giniatullin, C. Tassorelli and B. Davletov. "Double-Binding Botulinum Molecule with Reduced Muscle Paralysis: Evaluation in In Vitro and In Vivo Models of Migraine." Neurotherapeutics. DOI: 10.1007/s13311-020-00967-7

  • A.P. Andreou, M Fuccaro, G Lambru. The role of erenumab in the treatment of migraine. Ther Adv Neurol Disord. 2020; 13: 1756286420927119. DOI: 10.1177/1756286420927119

  • J. C. A. Edvinsson, A. Viganò, A. Alekseeva, E. Alieva, R. Arruda, C. De Luca, N. D’Ettore, I. Frattale, M. Kurnukhina, N. Macerola, E. Malenkova, M. Maiorova, A. Novikova, P. Řehulka, V. Rapaccini, O. Roshchina, G. Vanderschueren, L. Zvaune, A. P. Andreou, K. A. Haanes. The fifth cranial nerve in headaches. On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS), J Headache Pain. 2020; 21(1): 65 DOI: 10.1186/s10194-020-01134-1

  • G Lambru, B Hill, M Murphy, I Tylova, A.P. Andreou. A prospective real-world analysis of erenumab in refractory chronic migraine. J Headache Pain. 2020; 21(1): 61 DOI: 10.1186/s10194-020-01127-0

  • Andreou, A.P. and L. Edvinsson. Mechanisms of migraine as a chronic evolutive condition. J Headache Pain, 2019. 20(1): p. 117. DOI: 10.1186/s10194-019-1066-0

  • Alstadhaug, K.B. and A.P. Andreou. Caffeine and Primary (Migraine) Headaches-Friend or Foe? Front Neurol, 2019. 10: p. 1275. DOI: 10.3389/fneur.2019.01275

  • Lambru, G., A. P. Andreou, M. Guglielmetti and P. Martelletti. Emerging drugs for migraine treatment: an update. Expert Opin Emerg Drugs, 2018. 23(4): p. 301-318. DOI: 10.1080/14728214.2018.1552939

  • Andreou, A. P., M. Trimboli, A. Al-Kaisy, M. Murphy, S. Palmisani, C. Fenech, T. Smith and G. Lambru. Prospective real-world analysis of OnabotulinumtoxinA in chronic migraine post-National Institute for Health and Care Excellence UK technology appraisal. Eur J Neurol, 2018. 25(8): p. 1069-e83. DOI: 10.1186/s10194-020-01127-0

  • Trimboli, M., A. Al-Kaisy, A. P. Andreou, M. Murphy and G. Lambru. Non-invasive vagus nerve stimulation for the management of refractory primary chronic headaches: A real-world experience. Cephalalgia, 2018. 38(7): p. 1276-1285. DOI: 10.1177/0333102417731349

  • Lambru, G., A. P. Andreou, E. R. de la Torre and P. Martelletti. Tackling the perils of unawareness: the cluster headache case. J Headache Pain, 2017. 18(1): p. 49. DOI: 10.1186/s10194-017-0757-7

  • Torres-Perez, J. V., P. Santha, A. Varga, P. Szucs, J. Sousa-Valente, B. Gaal, M. Sivado, A. P. Andreou, S. Beattie, B. Nagy, K. Matesz, C. A. JS, G. Jancso and I. Nagy. Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain. Sci Rep, 2017. 7: p. 41221. DOI: 10.1038/srep41221

  • Jones, M. G., A. P. Andreou, S. B. McMahon and D. Spanswick. Pharmacology of reflex blinks in the rat: a novel model for headache research. J Headache Pain, 2016. 17(1): p. 96. DOI: 10.1186/s10194-016-0686-x

  • Andreou, A. P., P. R. Holland, S. Akerman, O. Summ, J. Fredrick and P. J. Goadsby. Transcranial magnetic stimulation and potential cortical and trigeminothalamic mechanisms in migraine. Brain, 2016. 139(Pt 7): p. 2002-14.DOI: 10.1007/s13311-020-00879-6

  • Andreou, A. P., M. Efthymiou, Y. Yu, H. R. Watts, F. H. Noormohamed, D. Ma, D. A. Lane and J. T. Crawley. Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke. PLoS One, 2015. 10(4): p. e0122410. DOI: 10.1371/journal.pone.0122410

  • Andreou, A. P., P. R. Holland, M. P. Lasalandra and P. J. Goadsby. Modulation of nociceptive dural input to the trigeminocervical complex through GluK1 kainate receptors. Pain, 2015. 156(3): p. 439-50. DOI: 10.1097/01.j.pain.0000460325.25762.c0​

  • Hoffmann, J., W. Supronsinchai, S. Akerman, A. P. Andreou, C. J. Winrow, J. Renger, R. Hargreaves and P. J. Goadsby. Evidence for orexinergic mechanisms in migraine. Neurobiol Dis, 2015. 74: p. 137-43. DOI: 10.1016/j.nbd.2014.10.022

  • Nagy, I., D. Friston, J. S. Valente, J. V. Torres Perez and A. P. Andreou. Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel. Prog Drug Res, 2014. 68: p. 39-76. DOI: 10.1007/978-3-0348-0828-6_2

  • Woldeamanuel, Y.W., A.P. Andreou, and R.P. Cowan. Prevalence of migraine headache and its weight on neurological burden in Africa: a 43-year systematic review and meta-analysis of community-based studies. J Neurol Sci, 2014. 342(1-2): p. 1-15. DOI: 10.1016/j.jns.2014.04.019

  • Park, J., H. Moon, S. Akerman, P. R. Holland, M. P. Lasalandra, A. P. Andreou, M. D. Ferrari, A. M. van den Maagdenberg and P. J. Goadsby. Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: a Fos protein study. Neurobiol Dis, 2014. 64: p. 1-7. DOI: 10.1016/j.nbd.2013.12.004

  • Sousa-Valente, J., A. P. Andreou, L. Urban and I. Nagy. Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics. Br J Pharmacol, 2014. 171(10): p. 2508-27. DOI: 10.1111/bph.12532

  • Varga, A., A. Jenes, T. H. Marczylo, J. Sousa-Valente, J. Chen, J. Austin, S. Selvarajah, F. Piscitelli, A. P. Andreou, A. H. Taylor, F. Kyle, M. Yaqoob, S. Brain, J. P. White, L. Csernoch, V. Di Marzo, L. Buluwela and I. Nagy. Anandamide produced by Ca(2+)-insensitive enzymes induces excitation in primary sensory neurons. Pflugers Arch, 2014. 466(7): p. 1421-35. DOI: s00424-013-1360-7

  • Holland, P. R., S. Akerman, A. P. Andreou, N. Karsan, J. A. Wemmie and P. J. Goadsby. Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura. Ann Neurol, 2012. 72(4): p. 559-63. DOI: 10.1002/ana.23653

  • Hoffmann, J., W. Supronsinchai, A. P. Andreou, O. Summ, S. Akerman and P. J. Goadsby. Olvanil acts on transient receptor potential vanilloid channel 1 and cannabinoid receptors to modulate neuronal transmission in the trigeminovascular system. Pain, 2012. 153(11): p. 2226-32. DOI: 10.1016/j.pain.2012.07.006

  • Sprenger, T., C. L. Seifert, M. Valet, A. P. Andreou, A. Foerschler, C. Zimmer, D. L. Collins, P. J. Goadsby, T. R. Tolle and M. M. Chakravarty. Assessing the risk of central post-stroke pain of thalamic origin by lesion mapping. Brain, 2012. 135(Pt 8): p. 2536-45. DOI: 10.1093/brain/aws153

  • Andreou, A.P. and P.J. Goadsby. Topiramate in the treatment of migraine: a kainate (glutamate) receptor antagonist within the trigeminothalamic pathway. Cephalalgia, 2011. 31(13): p. 1343-58. DOI: 10.1111/j.1538-7836.2011.04292.x

  • Mathew, R., A. P. Andreou, L. Chami, A. Bergerot, A. M. van den Maagdenberg, M. D. Ferrari and P. J. Goadsby. Immunohistochemical characterization of calcitonin gene-related peptide in the trigeminal system of the familial hemiplegic migraine 1 knock-in mouse. Cephalalgia, 2011. 31(13): p. 1368-80. DOI: 10.1177/0333102411418847

  • Andreou, A.P. and J.T. Crawley. Thrombomodulin analogues for the treatment of ischemic stroke. J Thromb Haemost, 2011. 9(6): p. 1171-3. DOI: 10.1177/0333102411418259

  • Summ, O., A. P. Andreou, S. Akerman and P. J. Goadsby. A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches. J Headache Pain, 2010. 11(6): p. 477-83. DOI: 10.1007/s10194-010-0263-7

  • Summ, O., A. R. Charbit, A. P. Andreou and P. J. Goadsby. Modulation of nocioceptive transmission with calcitonin gene-related peptide receptor antagonists in the thalamus. Brain, 2010. 133(9): p. 2540-8. DOI: 10.1093/brain/awq224

  • Andreou, A. P., O. Summ, A. R. Charbit, M. Romero-Reyes and P. J. Goadsby. Animal models of headache: from bedside to bench and back to bedside. Expert Rev Neurother, 2010. 10(3): p. 389-411. DOI: 10.1586/ern.10.16

  • Andreou, A.P., K.G. Shields, and P.J. Goadsby. GABA and valproate modulate trigeminovascular nociceptive transmission in the thalamus. Neurobiol Dis, 2010. 37(2): p. 314-23. DOI: 10.1016/j.nbd.2009.10.007

  • Andreou, A.P. and P.J. Goadsby. Therapeutic potential of novel glutamate receptor antagonists in migraine. Expert Opin Investig Drugs, 2009. 18(6): p. 789-803. DOI: 10.1517/13543780902913792

  • Andreou, A.P., P.R. Holland, and P.J. Goadsby. Activation of iGluR5 kainate receptors inhibits neurogenic dural vasodilatation in an animal model of trigeminovascular activation. Br J Pharmacol, 2009. 157(3): p. 464-73. DOI: 10.1111/j.1476-5381.2009.00142.x

  • Andreou, A., N. Dabarakis, A. Kagiava, E. K. Kosmidis, A. Geronikaki and G. Theophilidis. Assessing the effects of three dental impression materials on the isolated sciatic nerve of rat and frog. Toxicol In Vitro, 2007. 21(1): p. 103-8. DOI: 10.1016/j.tiv.2006.07.014

Book chapters


  • Animal Models of Migraine. Andreou AP, Oshinksy ML. Springer International Publishing Switzerland 2015 Ashina M., Geppetti P. (eds.), Pathophysiology of Headaches: From Molecule to Man, Headache, DOI 10.1007/978-3-319-15621-7_2 

  • Trigeminal Mechanisms of Nociception. Andreou AP, Edvinsson L. Springer International Publishing Switzerland 2020 Lambru G., Lanteri-Minet M. (eds.), Neuromodulation in Headache and Facial Pain Management; Principles, Rationale and Clinical Data DOI 10.1007/978-3-030-14121-9

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